FORMULPLEX ® is a complexation process with cyclodextrins in supercritical CO₂ medium.

It’s a new way to obtain inclusion complexes in mild conditions, and to improve bioavailability of poorly soluble drugs.

Cyclodextrins, a family of oligosaccharides, are commonly used to form inclusion complexes with hydrophobic organic molecules in order to enhance the Active Pharmaceutical Ingredient apparent solubility.

Therefore complexes obtained in supercritical CO₂ present structure characteristics different from those obtained with other techniques. An interesting property is that in many cases, the interactions between the active ingredient and the cyclodextrins are stronger, resulting in a higher apparent solubility of the resulting complex.